All beings fundamentally have no-self but we experience sufferings and afflictions because we attach to the ide of possessing a self. We often talk about achieving a state of selflessness or non-ego because the idea of a self is actually false and non-existent, but it’s hard enough just trying to ignore the physical body and its various sensations.
All the obstacles to attaining Enlightenment arise because we believe in the existence of a body and self, but if can ignore the body and abandon the idea of “ego”, then you can achieve Nirvana. So if we can get rid of the idea of a body and detach from the notions of possessing a self, we can ultimately reach enlightenment.
